Embryo Glue

EmbryoGlue is a medium developed by the company VitroLife to help embryo transfers implant in the uterus. The mix contains “all nutrients and energy sources needed for an optimal embryo development” and also contains hyaluronan – a protein that promotes implantation.[1]

One study found that it may improve implantation and ongoing pregnancy rates[2], but others have found the difference to be statistically insignificant, not helpful to those with previous IVF failures, or only useful to those with recurrent implantation failure.[3][4][5]

Ask your doctor if EmbryoGlue can help your case.

[1] “EmbryoGlue®.” n.d. Vitrolife. Accessed May 1, 2018. http://www.vitrolife.com/en/Products/G-SeriesTM-media/EmbryoGlue/.

[2] Valojerdi, Mojtaba Rezazadeh, Lila Karimian, Poopak Eftekhari Yazdi, Mohammad Ali Sadighi Gilani, Tahereh Madani, and Ahmad Reza Baghestani. 2006. “Efficacy of a Human Embryo Transfer Medium: A Prospective, Randomized Clinical Trial Study.” Journal of Assisted Reproduction and Genetics 23 (5). Springer US: 207–12. https://doi.org/10.1007/s10815-006-9031-7.

[3] Carrell, Douglas T, Benjamin R Emery, S. Kim, D. Kenigsberg, S. Brenner, and G. Moodie. 2008. “Use of Automated Imaging and Analysis Technology for the Detection of Aneuploidy in Human Sperm.” Fertility and Sterility 90 (2). Elsevier: 434–37. https://doi.org/10.1016/j.fertnstert.2007.06.095.

[4] Check, J H, D Summers-Chase, W Yuan, K Swenson, D Horwath, and M Press. 2012. “"Embryo Glue" Does Not Seem to Improve Chances of Subsequent Pregnancy in Refractory in Vitro Fertilization Cases.” Clinical and Experimental Obstetrics & Gynecology 39 (1): 11–12. http://www.ncbi.nlm.nih.gov/pubmed/22675945.

[5] Singh, Neeta, Monica Gupta, Alka Kriplani, and Perumal Vanamail. 2015. “Role of Embryo Glue as a Transfer Medium in the Outcome of Fresh Non-Donor in-Vitro Fertilization Cycles.” Journal of Human Reproductive Sciences 8 (4). Wolters Kluwer -- Medknow Publications: 214–17. https://doi.org/10.4103/0974-1208.170398.